Discovery of a new function of curcumin which enhances its anticancer therapeutic potency

نویسندگان

  • Koji Nagahama
  • Tomoya Utsumi
  • Takayuki Kumano
  • Saeko Maekawa
  • Naho Oyama
  • Junji Kawakami
چکیده

Curcumin has received immense attention over the past decades because of its diverse biological activities and recognized as a promising drug candidate in a large number of diseases. However, its clinical application has been hindered due to extremely low aqueous solubility, chemical stability, and cellular uptake. In this study, we discovered quite a new function of curcumin, i.e. pH-responsive endosomal disrupting activity, derived from curcumin's self-assembly. We selected anticancer activity as an example of biological activities of curcumin, and investigated the contribution of pH-responsive property to its anticancer activity. As a result, we demonstrated that the pH-responsive property significantly enhances the anticancer activity of curcumin. Furthermore, we demonstrated a utility of the pH-responsive property of curcumin as delivery nanocarriers for doxorubicin toward combination cancer therapy. These results clearly indicate that the smart curcumin assemblies act as promising nanoplatform for development of curcumin-based therapeutics.

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2016